BSI BS EN ISO 21676:2021

Current Consolidated
Water quality. Determination of the dissolved fraction of selected active pharmaceutical ingredients, transformation products and other organic substances in water and treated waste water. Method using high performance liquid chromatography and mass spectrometric detection (HPLC-MS/MS or -HRMS) after direct injection

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BSI BS EN ISO 21676:2021

Water quality. Determination of the dissolved fraction of selected active pharmaceutical ingredients, transformation products and other organic substances in water and treated waste water. Method using high performance liquid chromatography and mass spectrometric detection (HPLC-MS/MS or -HRMS) after direct injection

PUBLISH DATE 2021
PAGES 44
BSI BS EN ISO 21676:2021

This document specifies a method for the determination of the dissolved fraction of selected active pharmaceutical ingredients and transformation products, as well as other organic substances (see Table 1) in drinking water, ground water, surface water and treated waste water.

The lower application range of this method can vary depending on the sensitivity of the equipment used and the matrix of the sample. For most compounds to which this document applies, the range is ≥ 0,025 µg/l for drinking water, ground water and surface water, and ≥ 0,050 µg/l for treated waste water.

The method can be used to determine further organic substances or in other types of water (e.g. process water) provided that accuracy has been tested and verified for each case, and that storage conditions of both samples and reference solutions have been validated. Table 1 shows the substances for which a determination was tested in accordance with the method. Table E.1 provides examples of the determination of other organic substances.

Table 1

Substances for which a determination was tested in accordance with this method

Common name
Chemical name (IUPAC)a
Molecular
formula
Molar
mass
CAS-RNb
    g/mol  
4-Acetylaminoantipyrine

N-(2,3-Dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)acetamide

C13H15N3O2 245,28 83-15-8
N4-Acetyl sulfamethoxazole

N-{4-[(5-Methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl}-acetamide

C12H13N3O4S 295,32 21312-10-7
Diatrizoic acid (amidotricoic acid)

3,5-Bis(acetamido)-2,4,6-triiodobenzoic acid

C11H9I3N2O4 613,91 117-96-4
Atenolol

(RS)-2-[4-[2-Hydroxy-3-(1-methylethylamino) propoxy]phenyl]ethanamide

C14H22N2O3 266,34 29122-68-7
Bezafibrate

2-{4-[2-(4-Chlorbenzamido)ethyl]phenoxyl}-2-
methylpropanoic acid

C19H20ClNO4 361,80 41859-67-
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