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ISO 17734-1:2026

Workplace air - Determination of organonitrogen compounds in air using liquid chromatography and mass spectrometry - Part 1: Isocyanates using dibutylamine derivatives
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ISO 17734-1:2026

Workplace air - Determination of organonitrogen compounds in air using liquid chromatography and mass spectrometry - Part 1: Isocyanates using dibutylamine derivatives

PUBLISH DATE 2026
ISO 17734-1:2026

This document specifies a method for the determination of organic isocyanates in workplace air using derivatization with di-n-butylamine (DBA) and chromatographic analysis.

This document is applicable to the determination of a wide range of organic isocyanates present in both the gas phase and the particle phase in workplace atmospheres, including:

  • Monofunctional isocyanates such as isocyanic acid (ICA), methyl isocyanate (MIC), ethyl isocyanate (EIC), propyl isocyanate (PIC), butyl isocyanate (BIC) and phenyl isocyanate (PhI);
  • Monomeric diisocyanates, including 1,6-hexamethylene diisocyanate (HDI), 2,4- and 2,6-toluene diisocyanate (TDI), 4,4 -methylenediphenyl diisocyanate (MDI), 1,5-naphthyl diisocyanate (NDI), isophorone diisocyanate (IPDI) and 4,4 -dicyclohexylmethane diisocyanate (H12MDI); and
  • Multifunctional isocyanates, including oligomeric, prepolymeric and polymeric forms such as biuret-, isocyanurate- and allophanate-adducts.

The method covers air sampling using impingers, filters or combinations thereof, and analysis by liquid chromatography with mass spectrometric detection.

The useful analytical range is approximately 2.5 ng to 500 ng of isocyanate per sample. For a nominal air sample volume of 15 l, this corresponds to approximately 0.2 µg/m3 to 33 µg/m3. These values can vary depending on the isocyanate analysed.

This document does not apply to the determination of amines or aminoisocyanates. For the determination of amines and aminoisocyanates, the method specified in ISO 17734-2 [11].

SDO ISO: International Organization for Standardization
Document Number ISO 17734
Publication Date May 1, 2026
Language en - English
Page Count 40
Revision Level
Supercedes
Committee ISO/TC 146/SC 2
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