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ISO 23196:2022

Water quality - Calculation of biological equivalence (BEQ) concentrations
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ISO 23196:2022

Water quality - Calculation of biological equivalence (BEQ) concentrations

PUBLISH DATE 2022
ISO 23196:2022

This document specifies the derivation of biological equivalence (BEQ) concentrations for results of in vitro bioassays which are based on measuring effects on a biological process such as enzyme induction or cellular growth. The concept described here can be used for any biological assay after the proof of its applicability.

To derive BEQ concentrations, the effect on a biological process caused by a sample – i.e. the activity of the sample – is expressed in terms of a concentration of a reference compound which results in an equivalent effect on the process.

The term "sample" used in this document addresses:

  • environmental samples
  • defined mixtures
  • pure compounds used as test item in a bioassay.

BEQ concentrations can be derived for:

  • environmental water samples
  • extracts of environmental water samples including tap water
  • solutions of pure chemicals or mixtures of chemicals.
SDO ISO: International Organization for Standardization
Document Number ISO 23196
Publication Date Feb. 1, 2022
Language en - English
Page Count
Revision Level
Supercedes
Committee ISO/TC 147/SC 5
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